ADSORPTION OF PLATINUM-BASED ANTINEOPLASTIC AGENTS: USE OF RENEWABLE BIOMASSES FOR MONITORING IN SURFACE WATERS

Taciana Guarnieri Soares Guimarães; Alan Demarchi Jaccoud; Lucélia Alcantara Barros; Beatriz Costa França; Georgia Labuto

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Trabalho

Título do Trabalho

ADSORPTION OF PLATINUM-BASED ANTINEOPLASTIC AGENTS: USE OF RENEWABLE BIOMASSES FOR MONITORING IN SURFACE WATERS

Autores

Taciana Guarnieri Soares Guimarães
Alan Demarchi Jaccoud
Lucélia Alcantara Barros
Beatriz Costa França
Georgia Labuto

Modalidade

Resumo

Área temática

Biotecnologia ambiental e remediação

Data de Publicação

15/04/2024

País da Publicação

Brasil

Idioma da Publicação

Português

Página do Trabalho

https://www.even3.com.br/anais/xv-laseac-x-enqamb-2024i/787341-adsorption-of-platinum-based-antineoplastic-agents--use-of-renewable-biomasses-for-monitoring-in-surface-waters

ISBN

978-65-272-0404-6

Palavras-Chave

Cisplatin, Carboplatin, Oxaliplatin, Pre-concentration, Adsorption.

Resumo

Highlights • Activated biochars from renewable biomasses were used for platinum-based antineoplastics adsorption; • Complete antineoplastic adsorptions were achieved within 5 to 30 min. Abstract Platinum-based antineoplastic agents, namely cisplatin (CIS), carboplatin (CARBO), and oxaliplatin (OXALI), play a crucial role in treating various tumors, including pediatric cancers. In the state of São Paulo (Brazil) in 2022, a total of 382 kg of these molecules were marketed, of which, following administered doses, approximately 56% (OXALI) to 76% (CIS) are excreted in their unchanged form and reach surface waters, as sewage treatment systems remove only 1.85%1. This finding is alarming as these antineoplastics are not selective to rapidly growing cells, potentially causing carcinogenic and mutagenic effects and interfering with the endocrine system of any eukaryotic organism1. Hence, strategies for monitoring and removing these contaminants from aqueous environments become necessary, emphasizing adsorption methodologies. We investigated the adsorption capacity of these molecules by yeast waste (YW), cork powder (CP), old coffee grounds (CG), and sugar cane bagasse (SB), as well as their respective biochars and biochars activated with CO2, water vapor, and a combination of CO2 and water vapor. The biochars were obtained through the pyrolysis of biomass at 350°C for 1 hour under a nitrogen flow (0.01 mL/min), and the activated biochars underwent activation for 30 minutes at 600°C using a horizontal one-zone tubular furnace (FT-1200/H, Fortlab, Brazil). After a one-hour contact period between individual solutions of antineoplastics (C0 = 1 mg/L) and the adsorbent materials, the supernatants were analyzed by ICP-MS to determine the remaining concentrations of contaminants (in terms of total concentrations of 195Pt), using an internal standard (Tb). The highest adsorption capacities were obtained for biochars activated with CO2 and water vapor prepared from CG and SB, with respective adsorptions of 39% ± 7 and 42% ± 1 for CIS, 78% ± 1 and 66% ± 4 for CARBO, and 67% ± 3 and 73% ± 9 for OXALI. These results were statistically different from those obtained for the other evaluated adsorbents (ANOVA, 95% confidence). pH variation studies (pH 3, 7, and 9) over 1 hour of contact and adsorption kinetics (5, 10, 15, 30, and 60 minutes) were conducted using the best adsorbents at initial concentrations of 100 ng/L. Complete adsorption of the antineoplastics was achieved at pH 3 and 7, whereas for CARBO and OXALI, a reduction in adsorption occurred under basic conditions. This result is relevant due to the potential application of materials in natural water pH. Kinetic studies revealed that complete removal of CIS and CARBO by the evaluated adsorbents is possible in just 5 minutes of contact, whereas a minimum contact of 30 minutes is required for OXALI. These materials will be applied in the development of pre-concentration cartridges, where prior studies of adsorption isotherms will be conducted, along with their application in real water samples in competitive experiments, encompassing all three molecules simultaneously. For these purposes, an analytical method by HPLC-ICP-MS was developed, using water, methanol, and ammonium formate (20 mmol/L, 4% v/v methanol) as mobile phases, a flow rate of 0.25 mL/min, an injection volume of 3 µL, a furnace temperature of 45°C, and a run time of 23 minutes. The results indicate that the prepared adsorbents are effective for pre-concentrating these contaminants from aqueous environments in just a few minutes and under conditions of natural water pH, with the advantage of being derived from renewable biomass sources, potentially contributing to water security, bioeconomy, circular and green chemistry. Reference 1 Lenz et al. (2007), Water Sci. Technol. 56: 141-149. Acknowledgments FAPESP (2020/14419-7, 2022/08358-0, 2021/06471-1), CAPES, Biorigin, NESPEQUI (UNIFESP), NATEP (UNIFESP) and CEMU (UNIFESP)

Título do Evento: XV LASEAC - X ENQAmb 2024.
Cidade do Evento: Ouro Preto
Título dos Anais do Evento: Anais do XV LASEAC (Latin American Symposium on Environmental Analytical Chemistry) & X ENQAmb (Encontro Nacional de Química Ambiental)
Nome da Editora: Even3
Meio de Divulgação: Meio Digital

Como citar

GUIMARÃES, Taciana Guarnieri Soares et al.. ADSORPTION OF PLATINUM-BASED ANTINEOPLASTIC AGENTS: USE OF RENEWABLE BIOMASSES FOR MONITORING IN SURFACE WATERS.. In: . Disponível em: https//www.even3.com.br/anais/xv-laseac-x-enqamb-2024i/787341-ADSORPTION-OF-PLATINUM-BASED-ANTINEOPLASTIC-AGENTS--USE-OF-RENEWABLE-BIOMASSES-FOR-MONITORING-IN-SURFACE-WATERS. Acesso em: 24/06/2025