EXPLORING THE THERAPEUTIC POTENTIAL OF FLAVONES IN THE DISCOVERY OF TARGETS AGAINST GLIOBLASTOMA THROUGH NETWORK PHARMACOLOGY

Lucas Miguel de Carvalho; Nicolly Clemente de Melo

Paper Title

Authors

Lucas Miguel de Carvalho
Nicolly Clemente de Melo

Modality

Poster

Subject area

Systems Biology and Modeling

Publishing Date

21/11/2024

Country of Publishing

Brazil | Brasil

Language of Publishing

Inglês

Paper Page

https://www.even3.com.br/anais/xmeeting-2024/830078-exploring-the-therapeutic-potential-of-flavones-in-the-discovery-of-targets-against-glioblastoma-through-network-

ISBN

978-65-272-0843-3

Keywords

bioinformatics, network pharmacology, flavone, glioblastoma, cancer

Summary

Background: Flavones are a subset of flavonoids, abundant in foods like fruits, vegetables, teas, and grains, known for their antioxidant and anti-inflammatory properties. Among flavonoids, flavones exhibit unique bioactive characteristics. Studies highlight their potential to regulate cell cycle progression, manage oxidative stress, influence angiogenesis, and inhibit metastasis, suggesting promising anti-cancer properties. Glioblastoma is characterized by aggressive growth and low survival rates. Therefore, investigating flavones' effects on cancer is crucial. Flavones luteolin, apigenin, tangeritin, acacetin, and wogonin emerge from this research as potential candidates for therapeutic development, demonstrating anti-neuroinflammatory effects, indicating their broader applicability in tumor therapy. Employing network pharmacology, bioinformatics databases and molecular docking dynamics will help elucidate flavones' impact on glioblastoma to optimize therapeutic strategies. Objective: Prospect in silico targets of flavones in action with Glioblastoma. Methods: To prospect the anticancer targets for each flavone we used a network pharmacology pipeline. We selected the target genes of each flavone from their SMILE on the SwissTargetPrediction platform, and the glioblastoma targets were listed from the GeneCards, OMIM and PharmGKB databases. We generated anticancer targets from the intersection of the flavone’s target list with the general targets of glioblastoma. After, we applied network analysis to select the main target genes, and then performed ab initio docking between each flavone and selected the corresponded protein. Ultimately, the anticancer targets were also validated using gene expression data from public databases. Results: We identified 104 main anticancer targets common to all flavones. Network analysis showed a consistent hub-genes from each anticancer list for each flavone, being the genes MMP2, CDK1, EGFR, MMP9, GSK3B, SRC, PTGS2 with most appearance. Ligand-receptor docking showed that our finds highlight a list of consistent anticancer compounds targeting glioblastoma-related genes. Conclusion: Our pipeline based on network pharmacology and molecular docking demonstrates robust consistency in identifying potential anticancer targets specific to Glioblastoma across five distinct flavones, highlighting its efficacy in facilitating targeted drug discovery and optimization of therapeutic interventions for this aggressive form of cancer.

Title of the Event: 20º Congresso Brasileiro de Bioinformática: X-Meeting 2024
City of the Event: Salvador
Title of the Proceedings of the event: X-Meeting presentations
Name of the Publisher: Even3
Means of Dissemination: Meio Digital

How to cite

CARVALHO, Lucas Miguel de; MELO, Nicolly Clemente de. EXPLORING THE THERAPEUTIC POTENTIAL OF FLAVONES IN THE DISCOVERY OF TARGETS AGAINST GLIOBLASTOMA THROUGH NETWORK PHARMACOLOGY.. In: X-Meeting presentations. Anais...Salvador(BA) Hotel Deville Prime, 2024. Available in: https//www.even3.com.br/anais/xmeeting-2024/830078-EXPLORING-THE-THERAPEUTIC-POTENTIAL-OF-FLAVONES-IN-THE-DISCOVERY-OF-TARGETS-AGAINST-GLIOBLASTOMA-THROUGH-NETWORK-. Access in: 05/12/2025