CANDIDA ALBICANS MORPHOGENESIS AT DIFFERENT  TEMPORAL AND SPATIAL SCALES

Antonio Serrano; Charles Puerner; BASSILANA Martine; Robert Arkowitz

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Submission

Paper Title

CANDIDA ALBICANS MORPHOGENESIS AT DIFFERENT TEMPORAL AND SPATIAL SCALES

Authors

Antonio Serrano
Charles Puerner
BASSILANA Martine
Robert Arkowitz

Modality

Resumo

Subject area

IFBC - Morphogenes

Publishing Date

13/12/2022

Country of Publishing

Brasil

Language of Publishing

Inglês

Paper Page

https://www.even3.com.br/anais/isfus2021/531326-candida-albicans-morphogenesis-at-different--temporal-and-spatial-scales

ISBN

978-85-5722-449-0

Keywords

morphogenesis, branching, intracellular organization, growth rate, cytoplasm

Summary

We have a long-standing interest in how polarized growth is initiated and maintained during fungal development. In particular, we have been focusing on the yeast to hyphal transition and subsequent filamentous growth, in which growth is restricted to the apex in the human fungal pathogen, Candida albicans. We have been investigating the reorganization of different organelles during such growth processes including initial germ tube formation, subsequent filamentous growth and filament branch formation. In addition, recently we have been examining the physical characteristics of the cytoplasm in these different growth states. We have used loss of- and gain of- function mutants to probe the link between filament morphology and growth rate [1]. To investigate changes in the physical characteristics of the cytoplasm, i.e. cytoplasmic crowding and/or viscosity, we have been using a micro-rheology probe [2]. Based upon growth rate, morphology and the distribution of a range of cellular reporters, our results indicate that C. albicans hyphal branching and growth of the main hyphal filament are distinct developmental states. 1) C. Puerner et al. A myosin light chain is critical for fungal growth robustness in Candida albicans. mBio. 2021. 12: e0252821. 2) M. Delarue et al. mTORC1 controls phase separation and the biophysical properties of the cytoplasm by tuning crowding. Cell. 2018. 174: 338. ORAL PRESENTATION

Title of the Event: IV International Symposium on Fungal Stress - ISFUS & International Fungal Biology Conference - IFBC
City of the Event: São José dos Campos
Title of the Proceedings of the event: Annals of the XIII International Fungal Biology Conference (IFBC) & IV International Symposium on Fungal Stress (ISFUS)
Name of the Publisher: Even3
Means of Dissemination: Meio Digital

How to cite

SERRANO, Antonio et al.. CANDIDA ALBICANS MORPHOGENESIS AT DIFFERENT TEMPORAL AND SPATIAL SCALES.. In: Annals of the XIII International Fungal Biology Conference (IFBC) & IV International Symposium on Fungal Stress (ISFUS). Anais...São José dos Campos(SP) Hotel Nacional Inn, 2022. Available in: https//www.even3.com.br/anais/ISFUS2021/531326-CANDIDA-ALBICANS-MORPHOGENESIS-AT-DIFFERENT--TEMPORAL-AND-SPATIAL-SCALES. Access in: 18/07/2025