Anais do Congresso Brasileiro de Virologia & Encontro de Virologia do Mercosul

INVESTIGATION OF EPSTEIN-BARR VIRUS (EBV) AND HUMAN HERPESVIRUS 6 (HHV-6) INFECTION IN PATIENTS WITH MULTIPLE SCLEROSIS

Published in 04/01/2021 - ISBN: 978-65-5941-175-7

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DOI
10.29327/cbv.297637  
Paper Title
INVESTIGATION OF EPSTEIN-BARR VIRUS (EBV) AND HUMAN HERPESVIRUS 6 (HHV-6) INFECTION IN PATIENTS WITH MULTIPLE SCLEROSIS
Authors
  • Jéssica Gonçalves Pereira
  • Fabrícia Lima Fontes Dantas
  • Jéssica Vasques Raposo
  • Luciane Almeida Amado Leon
  • Vanessa Salete de Paula
  • Soniza Vieira Alves-Leon
Modality
Resumo
Subject area
Humana
Publishing Date
04/01/2021
Country of Publishing
Brasil
Language of Publishing
Inglês
Paper Page
https://www.even3.com.br/anais/cbv/297637-investigation-of-epstein-barr-virus-(ebv)-and-human-herpesvirus-6-(hhv-6)-infection-in-patients-with-multiple-scl
ISBN
978-65-5941-175-7
Keywords
multiple sclerosis, EBV, HHV-6
Summary
Multiple sclerosis (MS) is an autoimmune disease that affects the central nervous system (CNS) characterized by inflammation, demyelination, and neuronal damage. Environmental and genetic factors are associated with the risk of developing MS, but the exact cause still remains unidentified. Human herpesvirus-4 (HHV-4), also known as Epstein-Barr virus (EBV) and Human herpesvirus-6 (HHV-6) are latent viruses responsible for infections that can reactivate over the years and is among the most well-established environmental risk factors in MS. The risk of MS is low in patients who are EBV and HHV-6 negative but increases by several folds in individuals who have a history of infectious mononucleosis (IM). Targeting mechanisms by which EBV and HHV-6 is thought to participate in MS pathogenesis provides an opportunity understand better the activation and progression of MS. Although MS is considered a rare disease with 2.5 million patients worldwide and 35 thousand in Brazil alone, with an incidence of 15 cases for every 100 thousand inhabitants, it causes severe damage to the CNS, manifesting essential functional difficulties to a human being, such as cognitive changes, mobility and sensitivity. The aim of this study was to investigated the frequency of EBV and HHV-6 infection in patients with MS. For this, 200 blood plasma samples from MS patients were tested by real-time PCR assay for detection and quantification of EBV (EBNA-1) and HHV-6 (U56). Among these 200 patients, the average age found was 40.8 years, of which 33% (66/200) are male and 67% (134/200) are female. The detection of EBV and HHV-6 in MS patients were 9% (18/200) and 1.5% (3/200) respectively. These prevalences are considered low if compared to studies found in the literature. Regarding positive patients, for EBV there were 66.6% (2/3) male patients and 33.3% (1/3) female patients and for HHV-6, 38.9% (7/18) male patients and 61.1% (11/18) were female. These are the first data on the infection of these viruses in MS patients in Brazil. Genetic and immunologic markers will be analyzed to investigate the relationship between EBV and HHV-6 and MS, as well the relation between reactivation and disease development in different subtypes of disease. Financial Support: Capes
Title of the Event
XXXI Congresso Brasileiro de Virologia & XV Encontro de Virologia do Mercosul
Title of the Proceedings of the event
Anais do Congresso Brasileiro de Virologia & Encontro de Virologia do Mercosul
Name of the Publisher
Even3
Means of Dissemination
Meio Digital
DOI

How to cite

PEREIRA, Jéssica Gonçalves et al.. INVESTIGATION OF EPSTEIN-BARR VIRUS (EBV) AND HUMAN HERPESVIRUS 6 (HHV-6) INFECTION IN PATIENTS WITH MULTIPLE SCLEROSIS.. In: Congresso Brasileiro de Virologia & Encontro de Virologia do Mercosul. Anais...Porto Alegre(RS) Online, 2020. Available in: https//www.even3.com.br/anais/cbv/297637-INVESTIGATION-OF-EPSTEIN-BARR-VIRUS-(EBV)-AND-HUMAN-HERPESVIRUS-6-(HHV-6)-INFECTION-IN-PATIENTS-WITH-MULTIPLE-SCL. Access in: 13/05/2025

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