Anais do Congresso Brasileiro de Virologia & Encontro de Virologia do Mercosul

EVALUATION OF ANTIVIRAL POTENTIAL OF XANTHENEDIONES AND ITS TETRAKETONE INTERMEDIATES AGAINST MAYARO VIRUS.

Published in 04/01/2021 - ISBN: 978-65-5941-175-7

Link All Papers
Submission
DOI
10.29327/cbv.297130  
Paper Title
EVALUATION OF ANTIVIRAL POTENTIAL OF XANTHENEDIONES AND ITS TETRAKETONE INTERMEDIATES AGAINST MAYARO VIRUS.
Authors
  • Luciana de Souza Fernandes
  • Milene Lopes da Silva
  • Marcel Severino Da Silva Lucindo
  • Roberto Sousa Dias
  • Róbson Ricardo Teixeira
  • Sergio Oliveira de Paula
Modality
Resumo
Subject area
Humana
Publishing Date
04/01/2021
Country of Publishing
Brasil
Language of Publishing
Inglês
Paper Page
https://www.even3.com.br/anais/cbv/297130-evaluation-of-antiviral-potential-of-xanthenediones-and-its-tetraketone-intermediates-against-mayaro-virus
ISBN
978-65-5941-175-7
Keywords
arbovirus, mayaro, antivirals, xanthenediones
Summary
Arbovirosis are diseases caused by arthropod-borne viruses widely distributed worldwide. They represent a major public health problem, especially in tropical countries such as Brazil, which has favorable conditions for the development and spread of various arboviruses. Mayaro virus (MAYV) belongs to Togaviridae family and Alphavirus genus, transmitted by Haemagogus, Aedes and Anopheles mosquitoes. The viral infection in humans results in a febrile illness called Mayaro fever. Once sporadical and incidental, this disease has spreaded over urban areas as anthropic occupation advanced throughout forested areas. Although non-lethal, MAYV can result in a long-term debilitating arthralgia. Symptoms associated to this disease are similar to other febrile illnesses, which may impair correct diagnosis. Therefore, the search for new molecules able to fight the virus and not only the symptoms is a constant demand. Heterocyclic compounds containing a pyranosidic nucleus fused on both sides to cyclohex-2-enones rings are called 1,8-dioxooctahidroxantones or xanthenediones. These molecules have antifungicidal, anti-inflammatory, antibacterial, leishmanicidal and antitumor activity. Twenty-two xanthenedione and two tetraketone compounds were evaluated for their antiviral potential against MAYV. Antiviral screening was performed on virus-infected Vero cells in order to evaluate and quantify cell viability via MTT method. Eight compounds (03, 05, 07, 08, 09, 10, 12, 15, 16) were able to maintain cell viability above 50% and were considered inhibitors of viral infection. Furthermore, the 50% effective concentration (EC50) for each compound and their Selectivity Index were evaluated. Compounds 07 (EC50=8,40 µM) and 09 (EC50=21,17 µM) had the highest SI values: 10.8 and 15.8, respectively, and were selected for future mechanism assays. Given the absence of vaccines and specific treatments for Mayaro fever, the search for new therapeutic strategies to fight the disease is a constant demand. Xanthenediones may present a promising class of molecules for future testing against MAYV and other arbovirosis.
Title of the Event
XXXI Congresso Brasileiro de Virologia & XV Encontro de Virologia do Mercosul
Title of the Proceedings of the event
Anais do Congresso Brasileiro de Virologia & Encontro de Virologia do Mercosul
Name of the Publisher
Even3
Means of Dissemination
Meio Digital
DOI

How to cite

FERNANDES, Luciana de Souza et al.. EVALUATION OF ANTIVIRAL POTENTIAL OF XANTHENEDIONES AND ITS TETRAKETONE INTERMEDIATES AGAINST MAYARO VIRUS... In: Congresso Brasileiro de Virologia & Encontro de Virologia do Mercosul. Anais...Porto Alegre(RS) Online, 2020. Available in: https//www.even3.com.br/anais/cbv/297130-EVALUATION-OF-ANTIVIRAL-POTENTIAL-OF-XANTHENEDIONES-AND-ITS-TETRAKETONE-INTERMEDIATES-AGAINST-MAYARO-VIRUS. Access in: 27/12/2025

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