Proceedings of the 8th Brazilian Congress of Biotechnology

GENETIC ENGINEERING WITH QUANTUM CIRCUITS: CREATING CODES AND STUDYING BIOBLOQU GENETIC ELEMENTS

Published in 21/11/2025 - ISBN: 978-65-272-1865-4

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Paper Title
GENETIC ENGINEERING WITH QUANTUM CIRCUITS: CREATING CODES AND STUDYING BIOBLOQU GENETIC ELEMENTS
Authors
  • Patrícia Verdugo Pascoal
  • Deborah Ribeiro Bambil
  • LUISA MAYUMI ARAKE DE TACCA
  • Rayane Nunes Lima
  • Marco Antônio de Oliveira
  • Mendeli H. Vainstein
  • Elibio Rech
Modality
Abstract
Subject area
Technological Innovation;
Publishing Date
21/11/2025
Country of Publishing
Brazil | Brasil
Language of Publishing
en-US
Paper Page
https://www.even3.com.br/anais/biotecnologia2025/1256068-genetic-engineering-with-quantum-circuits--creating-codes-and-studying-biobloqu-genetic-elements
ISBN
978-65-272-1865-4
Keywords
Quantum computing. BioBloQu. Simulation. Biotechnology. Brazilian Biomes.
Summary
The accelerated exploration and engineering of nucleotide sequences are directed towards quantum mechanics and their intrinsic entanglements, implementing the qubits states, including the development of algorithms. The production rate of biological sequencing data has increased to approximately 1 Gb/h, but the ability to analyze these data has not kept pace due to complexity issues and the limitations of classic computing. Despite its own challenges, quantum computing offers a potential solution for analyzing biological data and extracting relevant information. We aimed at developing and implementing quantum algorithms that drive searches for genetic information and allow the assembly of prototype transcriptional units with increased efficiency as a promising alternative for future design of synthetic genomes. We developed Qubio.py, a quantum computing tool based in Goover’s Algorithm to precisely search for a 50 nt target sequence in a DNA sequence database with up to 3022 nucleotides. Two codes were written, one to detect a Cas9 functional domain in a metagenomic database of Brazilian biomes and one to detect specific regions in the synthetic genome of the minimal cell approximation Mycoplasma mycoides JCVI-Syn3B. A third code was created to assemble transcriptional units comprising promoter, RBS, ORF and terminator sequences, which we named BioBloQu. All analysis were performed on the IBM Quantum Experience platform, which used a quantum simulator processor with 36 qubits. All codes could produce the expected outputs. For the prospection, we detected a 50nt sequence of a Cas9 functional domain in a metagenomic database, which were then used as pseudo-ORF in the assembly of a BioBloQu. The search in JCVI-3B minimal genome identified a promising region for insertion of the BioBloQu created, as an initial example of guided genome engineering in a quantum environment. Our algorithm constitutes a unique starting point for developing a more sophisticated model for the manipulation of data. This tool could be exploited for quantum-enhanced design, building synthetic genomes with desirable traits from the bottom up and exploiting genetic big data. Enhancing the algorithm and expanding device availability are significant targets for accelerating searches and gathering specific biodiversity features for research and applications.
Title of the Event
8th Brazilian Biotechnology Congress.
City of the Event
Natal
Title of the Proceedings of the event
Proceedings of the 8th Brazilian Congress of Biotechnology
Name of the Publisher
Even3
Means of Dissemination
Meio Digital

How to cite

PASCOAL, Patrícia Verdugo et al.. GENETIC ENGINEERING WITH QUANTUM CIRCUITS: CREATING CODES AND STUDYING BIOBLOQU GENETIC ELEMENTS.. In: Proceedings of the 8th Brazilian Congress of Biotechnology. Anais...Natal(RN) Hotel Praia Mar, 2025. Available in: https//www.even3.com.br/anais/biotecnologia2025/1256068-GENETIC-ENGINEERING-WITH-QUANTUM-CIRCUITS--CREATING-CODES-AND-STUDYING-BIOBLOQU-GENETIC-ELEMENTS. Access in: 20/06/2026

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