X-Meeting presentations

REVIEWING CARBAPENEM RESISTANCE PHENOMENON OF ACINETOBACTER BAUMANNII THROUGH A META-ANALYSIS

Published in 08/11/2023 - ISBN: 978-65-272-0061-1

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Paper Title
REVIEWING CARBAPENEM RESISTANCE PHENOMENON OF ACINETOBACTER BAUMANNII THROUGH A META-ANALYSIS
Authors
  • Diego Lucas Neres Rodrigues
  • Francielly Rodrigues da Costa
  • Wanderson Marques da Silva
  • Flávia Figueira Aburjaile
  • Vasco A de C Azevedo
Modality
Poster
Subject area
DNA and Genomics
Publishing Date
08/11/2023
Country of Publishing
Brazil | Brasil
Language of Publishing
Inglês
Paper Page
https://www.even3.com.br/anais/xmeeting2023/643476-reviewing-carbapenem-resistance-phenomenon-of-acinetobacter-baumannii-through-a-meta-analysis
ISBN
978-65-272-0061-1
Keywords
CRAB, infection, resistance, carbapenem
Summary
Acinetobacter baumannii is a Gram-negative coccobacillus, which is catalase-positive and oxidase-negative. According to the World Health Organization, it is one of the most important nosocomial pathogens and a great resistance model to antimicrobials. This organism is related to several comorbidities such as pneumonia, bacteremia, cystitis, and meningitis, among others. As a pathogen, it also has increasing relevance to one health by being able to infect livestock and pets. A major problem of infections with this pathogen is its intrinsic resistance to beta-lactams, especially carbapenems. With this in mind, efforts to identify causalities and reasons that justify and solve the constant increase in the number of resistant bacterial isolates are always worthwhile, since it is estimated that by 2050 there will be about 10 million fatalities from diseases caused by resistant bacteria. Therefore, the objective of this study was, by means of a systematic review and meta-analysis, to evaluate the development of beta-lactam resistance in A. baumannii over time from the year 2000 to 2020. For this purpose, papers were searched using the keywords “Acinetobacter baumannii” AND “beta-lactam” OR “penicillin” OR “cephalosporin” OR “cephamycin” OR “carbapenem”; OR “monobactam”, published from 2000 to 2020 in English language, totaling 77,664 results. Papers retrieved were automatically filtered using an in house script in python3. As a result, papers that did not mention the target organism in the title, abstract or keywords were excluded from the analysis, yielding a total of 2,576 papers. Next, papers that provided statistically supported data for a meta-analysis were selected, totaling 8 papers eligible for statistical analysis. As a main result, it is possible to state with a p-value less than 0.01 that A. baumannii has a more than 3 times greater chance of having carbapenem resistance when compared to other bacterial species, which corroborates with statistical and epidemiological data released by health agencies worldwide. This data is of concern because it indicates that beta-lactam-based treatments (particularly carbapenems) tend to be less effective against A. baumannii, even when compared to Pseudomonas aeruginosa.
Title of the Event
X-Meeting / BSB 2023
City of the Event
Curitiba
Title of the Proceedings of the event
X-Meeting presentations
Name of the Publisher
Even3
Means of Dissemination
Meio Digital

How to cite

RODRIGUES, Diego Lucas Neres et al.. REVIEWING CARBAPENEM RESISTANCE PHENOMENON OF ACINETOBACTER BAUMANNII THROUGH A META-ANALYSIS.. In: X-Meeting presentations. Anais...Curitiba(PR) Campus da indústria, 2023. Available in: https//www.even3.com.br/anais/xmeeting2023/643476-REVIEWING-CARBAPENEM-RESISTANCE-PHENOMENON-OF-ACINETOBACTER-BAUMANNII-THROUGH-A-META-ANALYSIS. Access in: 18/07/2025

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