X-Meeting presentations

IDENTIFICATION OF TISSUE-SPECIFIC LONG NON-CODING RNAS ASSOCIATED WITH SKELETAL MUSCLE AND ADIPOSE TISSUE WASTING IN CANCER CACHEXIA

Published in 08/11/2023 - ISBN: 978-65-272-0061-1

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Paper Title
IDENTIFICATION OF TISSUE-SPECIFIC LONG NON-CODING RNAS ASSOCIATED WITH SKELETAL MUSCLE AND ADIPOSE TISSUE WASTING IN CANCER CACHEXIA
Authors
  • Fernando de Souza Leite
  • Amanda Piveta Schnepper
  • Victória Larissa Schimidt Camargo
  • Sarah Santiloni Cury
  • Ana Luiza Labbate Bonaldo
  • Jakeline Santos Oliveira
  • Caio Fernando Ferreira Mussatto
  • Robson Carvalho
Modality
Poster
Subject area
RNA and transcriptomics
Publishing Date
08/11/2023
Country of Publishing
Brazil | Brasil
Language of Publishing
en-US
Paper Page
https://www.even3.com.br/anais/xmeeting2023/643332-identification-of-tissue-specific-long-non-coding-rnas-associated-with-skeletal-muscle-and-adipose-tissue-wasting
ISBN
978-65-272-0061-1
Keywords
tissue-specific lncRNAs, differential expression, microarray
Summary
Cancer cachexia is a multifactorial syndrome characterized by progressive weight loss in cancer patients, with specific losses of skeletal muscle and adipose tissue. Despite its impact on cancer patients, the exact mechanisms underlying skeletal muscle and adipose tissue wasting have not yet been fully elucidated. Recent research has shown that long non-coding RNAs (lncRNAs), a class of non-coding RNAs that are > 200 nt in length, play a significant role in metabolic abnormalities. The objective of this study was to identify lncRNAs associated with the complex mechanisms underlying the metabolic alterations of tissues severely affected by cancer cachexia. We searched for all microarray datasets publicly available in the GEO datasets (NCBI). Then, each dataset was analyzed using GEO2R to identify the differentially expressed genes (DEG) between control and cachectic groups. The 24 datasets covered a range of tumor types and models, as well as different tissue types including muscle, adipose, brain, and liver samples from both humans (n = 176) and mice (n = 80). We found 128 tissue-specific lncRNAs in humans, with 67 been expressed in abdominal muscles and 26 in intra-abdominal adipose tissue. Only six lncRNAs (ADAMTSL4-AS1, BAALC-AS2, MIR100HG, DIO3OS, VLDLR-AS1, MIRLET7BHG) were shared between two or more human tissues. In mice, abdominal muscles also showed a high number of differentially expressed lncRNAs (44), with only 66 being shared between tissue. These tissue-specific features of lncRNAs make them potential mediators or therapeutic targets for cancer-associated cachexia. In conclusion, we identified tissue-specific lncRNAs associated with cachexia in humans and mice by analyzing microarray datasets from different tissue types. The tissue-specific features of lncRNAs make them potential mediators or therapeutic targets for the syndrome. The identification of specific lncRNAs associated with cachexia in different tissues can guide future co-expression studies and lead to the development of targeted treatments for cancer patients with cachexia.
Title of the Event
X-Meeting / BSB 2023
City of the Event
Curitiba
Title of the Proceedings of the event
X-Meeting presentations
Name of the Publisher
Even3
Means of Dissemination
Meio Digital

How to cite

LEITE, Fernando de Souza et al.. IDENTIFICATION OF TISSUE-SPECIFIC LONG NON-CODING RNAS ASSOCIATED WITH SKELETAL MUSCLE AND ADIPOSE TISSUE WASTING IN CANCER CACHEXIA.. In: X-Meeting presentations. Anais...Curitiba(PR) Campus da indústria, 2023. Available in: https//www.even3.com.br/anais/xmeeting2023/643332-IDENTIFICATION-OF-TISSUE-SPECIFIC-LONG-NON-CODING-RNAS-ASSOCIATED-WITH-SKELETAL-MUSCLE-AND-ADIPOSE-TISSUE-WASTING. Access in: 30/04/2026

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