EFFICACY OF FLURALANER ADMINISTERED ORALLY IN CONTROLLING RHIPICEPHALUS MICROPLUS TICKS IN CATTLE

THAÖNE LOPES BUENO; Fernanda Ferreira Salgueiro; Hugo Rocha Sabença Dias; Laritssa Andrade Pinheiro Magalhães; Fábio Scott; Gabriela Ferreira de Oliveira; THAIS RIBEIRO CORREIA AZEVEDO

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Trabalho

Título do Trabalho

EFFICACY OF FLURALANER ADMINISTERED ORALLY IN CONTROLLING RHIPICEPHALUS MICROPLUS TICKS IN CATTLE

Autores

THAÖNE LOPES BUENO
Fernanda Ferreira Salgueiro
Hugo Rocha Sabença Dias
Laritssa Andrade Pinheiro Magalhães
Fábio Scott
Gabriela Ferreira de Oliveira
THAIS RIBEIRO CORREIA AZEVEDO

Modalidade

Resumo Simples

Área temática

Ectoparasitos: sistemática, epidemiologia e controle

Data de Publicação

22/05/2026

País da Publicação

Brasil

Idioma da Publicação

pt-BR

Página do Trabalho

https://www.even3.com.br/anais/x-simposio-internacional-ciencias-veterinarias/1431969-efficacy-of-fluralaner-administered-orally-in-controlling-rhipicephalus-microplus-ticks-in-cattle

ISBN

978-65-272-2456-3

Palavras-Chave

acaricide, isoxazolines, resistance, stable test, treatment

Resumo

The cattle tick, Rhipicephalus (Boophilus) microplus, is one of the main sanitary challenges faced by livestock farming in tropical and subtropical countries, including Brazil, where climatic conditions favor its survival throughout the territory. It is estimated that more than 80% of the global cattle population faces infestations by this ectoparasite. Its parasitism can reduce weight gain, cause anemia, increase the risk of myiasis, and even transmit pathogens such as Babesia bovis, Babesia bigemina, and Anaplasma marginale, etiological agents of the bovine parasitic sadness complex. Due to these impacts, the annual economic losses associated with the tick are estimated at approximately US$3.24 million. Traditional control methods include integrated management practices, such as selection of more resistant breeds, rational herd management, and pasture rotation, in addition to the use of acaricides. The excessive and inappropriate use of the latter has intensified tick resistance to different chemical classes, limiting the effectiveness of available treatments. In this scenario, isoxazolines have emerged as a promising solution. Fluralaner, a member of this class, has shown efficacy above 90% against R. microplus infestations and was approved in Brazil in 2022 in a pour-on formulation. With the aim of expanding control options and overcoming the challenges posed by resistance, this project proposes to evaluate the use of Fluralaner in a paste formulation for oral administration, exploring its potential in the strategic management of R. microplus in stabled cattle. For this purpose, 16 experimentally infested cattle, aged between six months and two years and weighing between 100 and 300 kg, will be used. The infestation procedure will occur during pre-treatment, on alternate days, from D-25 to D-1. During this procedure, the animals will be restrained for two hours using a halter, rope, and tail tying, ensuring adequate conditions for larval attachment. After ranking on days D-3, D-2, and D-1, the animals will be divided into two groups, Treated and Control, and on day D-0, the treated group will receive oral treatment with Fluralaner. R. microplus infestations will be maintained after treatment until efficacy is less than 80%. Teleogynes will be collected daily after treatment and subsequently analyzed from D+1 to D+84 to assess reproduction and viability. It is expected that orally administered fluralaner will provide rapid and effective control of ticks, favored by its accelerated absorption by the gastrointestinal tract and high systemic bioavailability. The drug's action should result in rapid induction of toxicity and death of ectoparasites, with a minimum efficacy of 80%, in addition to promoting a prolonged effect in controlling infestations.

Título do Evento: X Simpósio Internacional em Ciências Veterinárias | X International Symposium in Veterinary Sciences
Cidade do Evento: Seropédica
Título dos Anais do Evento: Anais do X Simpósio Internacional em Ciências Veterinárias (X SINCVET)
Nome da Editora: Even3
Meio de Divulgação: Meio Digital

Como citar

BUENO, THAÖNE LOPES et al.. EFFICACY OF FLURALANER ADMINISTERED ORALLY IN CONTROLLING RHIPICEPHALUS MICROPLUS TICKS IN CATTLE.. In: Anais do X Simpósio Internacional em Ciências Veterinárias (X SINCVET). Anais...Seropédica(RJ) UFRRJ, 2025. Disponível em: https//www.even3.com.br/anais/x-simposio-internacional-ciencias-veterinarias/1431969-EFFICACY-OF-FLURALANER-ADMINISTERED-ORALLY-IN-CONTROLLING-RHIPICEPHALUS-MICROPLUS-TICKS-IN-CATTLE. Acesso em: 06/11/2026