ELECTROSPUN POLY(Ε-CAPROLACTONE) AND POLY(N-VINYL-2-PYRROLIDONE) MATS CONTAINING BIOACTIVE COMPOUNDS FROM RED PROPOLIS AND CURCUMA LONGA L.

Higor De Souza Silva; Fernando Rogério de Paula; Ligia M. Manzine Costa; Eloisa Aparecida Carvalho Silva; Kaila P. Medina Alarcón; Pedro Henrique Trindade Pereira

Título do Trabalho

Autores

Higor De Souza Silva
Fernando Rogério de Paula
Ligia M. Manzine Costa
Eloisa Aparecida Carvalho Silva
Kaila P. Medina Alarcón
Pedro Henrique Trindade Pereira

Modalidade

Pôster - resumo

Área temática

Materiais e biomateriais

Data de Publicação

27/05/2026

País da Publicação

Brasil

Idioma da Publicação

pt-BR

Página do Trabalho

https://www.even3.com.br/anais/workshop-do-ineo-2026/1456798-electrospun-poly(e-caprolactone)-and-poly(n-vinyl-2-pyrrolidone)-mats-containing-bioactive-compounds-from-red-pr

ISBN

978-65-272-2467-9

Palavras-Chave

Polycaprolactone; Polyvinylpyrrolidone; Red propolis; Curcuma longa L.; Electrospinning; Wound dressings.

Resumo

The search for biomaterials with therapeutic properties has been a growing field of research, particularly in the development of functional dressings that promote wound healing and infection prevention. In this study, electrospun mats were developed from blends of poly(e-caprolactone) (PCL) and poly(N-vinyl-2-pyrrolidone) (PVP), incorporating bioactive compounds from red propolis and Curcuma longa L. to promote antibacterial activity and accelerate the healing process. The characterization of the extracts revealed high levels of bioactive compounds, with red propolis presenting 231.3 mg GAE/g of total phenols, 31.8 mg QE/g of flavonoids, and an antioxidant capacity of 90.29% according to the DPPH radical assay, while Curcuma longa L. exhibited 42.4 mg GAE/g of phenols, 13.6 mg QE/g of flavonoids, and an antioxidant capacity of 58.46%, indicating the potential of these compounds to neutralize free radicals. Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) tests demonstrated that the extracts were effective mainly against Gram-positive pathogens and that the electrospun polymeric matrices enhanced their inhibitory capacity. The mats were produced by electrospinning, resulting in microfibers with an average diameter of 1.79 µm, as observed by Scanning Electron Microscopy (SEM). Interactions between the bioactive compounds and the polymer matrix were analyzed using Fourier Transform Infrared Spectroscopy (FTIR), while thermal properties were evaluated by Thermogravimetric Analysis (TGA) and Derivative Thermogravimetric Analysis (DTG), indicating immiscibility of the blends. Mechanical testing showed that the incorporation of PCL increased the strength of PVP, improving the overall mechanical performance of the biomaterial. Wettability tests revealed that the addition of PVP reduced the hydrophobicity of the blends, increasing their hydrophilicity even in the presence of the functional compounds, and release studies demonstrated an initial burst release of bioactive compounds during the first hours. Overall, the results indicate that the developed electrospun mats exhibit promising properties for application as functional dressings, with the potential to enhance wound healing and prevent infections. Acknowledgments: FAPESP (2025/27044-5), CNPq (408449/2024-1), the Department of Physics and Chemistry (DFQ), and the Graduate Program in Materials Science (PPGCM) at São Paulo State University (UNESP) – Ilha Solteira School of Engineering (FEIS).

Título do Evento: Workshop do INEO 2026
Cidade do Evento: Nazaré Paulista
Título dos Anais do Evento: Anais do Workshop do INEO 2026
Nome da Editora: Even3
Meio de Divulgação: Meio Digital

Como citar

SILVA, Higor De Souza et al.. ELECTROSPUN POLY(Ε-CAPROLACTONE) AND POLY(N-VINYL-2-PYRROLIDONE) MATS CONTAINING BIOACTIVE COMPOUNDS FROM RED PROPOLIS AND CURCUMA LONGA L... In: Anais do Workshop do INEO 2026. Anais...Nazaré Paulista(SP) Hotel Estância Atibainha, 2026. Disponível em: https//www.even3.com.br/anais/workshop-do-ineo-2026/1456798-ELECTROSPUN-POLY(E-CAPROLACTONE)-AND-POLY(N-VINYL-2-PYRROLIDONE)-MATS-CONTAINING-BIOACTIVE-COMPOUNDS-FROM-RED-PR. Acesso em: 10/08/2026