SYNTHESIS OF POLYMER-CAPPED CORE@SHELL CU@AG NANOALLOYS FOR ANTIMICROBIAL APPLICATIONS

Bruna Naemi Harada; Vitor Gonçalves Vital; Suzan Pantaroto de Vasconcellos; Diogo Silva Pellosi

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Paper Title

SYNTHESIS OF POLYMER-CAPPED CORE@SHELL CU@AG NANOALLOYS FOR ANTIMICROBIAL APPLICATIONS

Authors

Bruna Naemi Harada
Vitor Gonçalves Vital
Suzan Pantaroto de Vasconcellos
Diogo Silva Pellosi

Modality

Pôster

Subject area

Síntese e caracterização de materiais

Publishing Date

12/12/2023

Country of Publishing

Brasil

Language of Publishing

Inglês

Paper Page

https://www.even3.com.br/anais/workshop-do-ineo-2023/613267-synthesis-of-polymer-capped-coreshell-cuag-nanoalloys-for-antimicrobial-applications

ISBN

978-65-272-0088-8

Keywords

nanoparticles, bacteria, silver, copper, synergism

Summary

Microorganisms have been a growing concern due to the rapid expansion of multi-resistant antibiotic strains. Therefore, discover of new drugs is urgent. Among several alternatives, silver nanoparticles (AgNP) stand out, but their high cost and human toxicity has limited its use [1]. An alternative are copper nanoparticles (CuNP), a metal with lower cost and a broad spectrum of action, but easily oxidized in an aqueous medium [2]. In this scenario, we propose here the synergic use of Ag and Cu through the production of Ag/CuNP nanoalloys aiming a high multifocal antimicrobial activity, lower cost, higher biocompatibility and kinetic stability. Previous synthesis demonstrated that Ag/Cu alloys did not presented the required solution because cooper exposition to water, even in the presence of silver, lead to nanoparticle oxidation. Therefore, we planned the synthesis of a Cu@Ag core-shell structure in which silver exposition on the external layer of the nanoparticle avoid copper oxidation process [3]. In addition, we applied the organic polymer polyvinylpyrrolidone (PVP) as capping agent in order to increase nanoparticle’s stability and solubility in aqueous media. The synthetisized nanolloys presented a strong visible light absorption due plasmon resonance of both nanometasls [1]. DLS measurements confirmed the nanosize of the synthesized particles and a low polydispersion. TEM images demonstrated a spherical shape and confirmed the size of the particles. SAED, EDS and XRD measurements also confirmed the chemical and crystalline nature of Cu@AgNPs. Antimicrobial activity of nanoalloys in E. coli and S. aureus clearly demonstrated that the creation of nannolloys synergistically increased antimicrobial action of Cu@Ag alloys with high content of Cu in their composition. These promising results augurs well for further developments of Cu@Ag nanoalloys aiming inactivation of multi-resistant bacteria. References: [1] S. Shaikh, N. et al. Mechanistic Insights into the Antimicrobial Actions of Metallic Nanoparticles and Their Implications for Multidrug Resistance. Int. J. Mol. Sci. 20(10), 2468 (2019). [2] L. Rout, et al. Bimetallic Ag–Cu Alloy Nanoparticles as a Highly Active Catalyst for the Enamination of 1,3-Dicarbonyl Compounds. RSC Adv. 6(55), 49923 (2016). [3] S. Shang, et al. Synthesis of Cu@Ag core–shell nanoparticles for characterization of thermal stability and electric resistivity. Applied Physics. 124, 492 (2018).

Title of the Event: Workshop do INEO 2023
City of the Event: Nazaré Paulista
Title of the Proceedings of the event: Anais do Workshop INEO 2023
Name of the Publisher: Even3
Means of Dissemination: Meio Digital
DOI: Get DOI

How to cite

HARADA, Bruna Naemi et al.. SYNTHESIS OF POLYMER-CAPPED CORE@SHELL CU@AG NANOALLOYS FOR ANTIMICROBIAL APPLICATIONS.. In: Anais do workshop INEO 2023. Anais...Nazaré Paulista(SP) Hotel Estância Atibainha, 2023. Available in: https//www.even3.com.br/anais/workshop-do-ineo-2023/613267-SYNTHESIS-OF-POLYMER-CAPPED-CORESHELL-CUAG-NANOALLOYS-FOR-ANTIMICROBIAL-APPLICATIONS. Access in: 27/07/2024