SYNTHESIS OF POLYMER-CAPPED CORE@SHELL CU@AG NANOALLOYS FOR ANTIMICROBIAL APPLICATIONS

Published in 12/12/2023 - ISBN: 978-65-272-0088-8

Paper Title
SYNTHESIS OF POLYMER-CAPPED CORE@SHELL CU@AG NANOALLOYS FOR ANTIMICROBIAL APPLICATIONS
Authors
  • Bruna Naemi Harada
  • Vitor Gonçalves Vital
  • Suzan Pantaroto de Vasconcellos
  • Diogo Silva Pellosi
Modality
Pôster
Subject area
Síntese e caracterização de materiais
Publishing Date
12/12/2023
Country of Publishing
Brasil
Language of Publishing
Inglês
Paper Page
https://www.even3.com.br/anais/workshop-do-ineo-2023/613267-synthesis-of-polymer-capped-coreshell-cuag-nanoalloys-for-antimicrobial-applications
ISBN
978-65-272-0088-8
Keywords
nanoparticles, bacteria, silver, copper, synergism
Summary
Microorganisms have been a growing concern due to the rapid expansion of multi-resistant antibiotic strains. Therefore, discover of new drugs is urgent. Among several alternatives, silver nanoparticles (AgNP) stand out, but their high cost and human toxicity has limited its use [1]. An alternative are copper nanoparticles (CuNP), a metal with lower cost and a broad spectrum of action, but easily oxidized in an aqueous medium [2]. In this scenario, we propose here the synergic use of Ag and Cu through the production of Ag/CuNP nanoalloys aiming a high multifocal antimicrobial activity, lower cost, higher biocompatibility and kinetic stability. Previous synthesis demonstrated that Ag/Cu alloys did not presented the required solution because cooper exposition to water, even in the presence of silver, lead to nanoparticle oxidation. Therefore, we planned the synthesis of a Cu@Ag core-shell structure in which silver exposition on the external layer of the nanoparticle avoid copper oxidation process [3]. In addition, we applied the organic polymer polyvinylpyrrolidone (PVP) as capping agent in order to increase nanoparticle’s stability and solubility in aqueous media. The synthetisized nanolloys presented a strong visible light absorption due plasmon resonance of both nanometasls [1]. DLS measurements confirmed the nanosize of the synthesized particles and a low polydispersion. TEM images demonstrated a spherical shape and confirmed the size of the particles. SAED, EDS and XRD measurements also confirmed the chemical and crystalline nature of Cu@AgNPs. Antimicrobial activity of nanoalloys in E. coli and S. aureus clearly demonstrated that the creation of nannolloys synergistically increased antimicrobial action of Cu@Ag alloys with high content of Cu in their composition. These promising results augurs well for further developments of Cu@Ag nanoalloys aiming inactivation of multi-resistant bacteria. References: [1] S. Shaikh, N. et al. Mechanistic Insights into the Antimicrobial Actions of Metallic Nanoparticles and Their Implications for Multidrug Resistance. Int. J. Mol. Sci. 20(10), 2468 (2019). [2] L. Rout, et al. Bimetallic Ag–Cu Alloy Nanoparticles as a Highly Active Catalyst for the Enamination of 1,3-Dicarbonyl Compounds. RSC Adv. 6(55), 49923 (2016). [3] S. Shang, et al. Synthesis of Cu@Ag core–shell nanoparticles for characterization of thermal stability and electric resistivity. Applied Physics. 124, 492 (2018).
Title of the Event
Workshop do INEO 2023
City of the Event
Nazaré Paulista
Title of the Proceedings of the event
Anais do Workshop INEO 2023
Name of the Publisher
Even3
Means of Dissemination
Meio Digital
DOI
LinkGet DOI

How to cite

HARADA, Bruna Naemi et al.. SYNTHESIS OF POLYMER-CAPPED CORE@SHELL CU@AG NANOALLOYS FOR ANTIMICROBIAL APPLICATIONS.. In: Anais do workshop INEO 2023. Anais...Nazaré Paulista(SP) Hotel Estância Atibainha, 2023. Available in: https//www.even3.com.br/anais/workshop-do-ineo-2023/613267-SYNTHESIS-OF-POLYMER-CAPPED-CORESHELL-CUAG-NANOALLOYS-FOR-ANTIMICROBIAL-APPLICATIONS. Access in: 20/06/2024

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