STUDY OF REGULATORY PROTEINS IN SALMONELLA ENTERICA AND SHIGELLA FLEXNERI

Publicado em 09/06/2023 - ISBN: 978-85-5722-785-9

Título do Trabalho
STUDY OF REGULATORY PROTEINS IN SALMONELLA ENTERICA AND SHIGELLA FLEXNERI
Autores
  • Yessica Paola Jaimes Florez
  • Isabella Carolina Rodrigues dos Santos Goes
  • Genesy Perez Jorge
  • Marcelo Brocchi
Modalidade
Apresentação de Pôster
Área temática
Genética de Microrganismos
Data de Publicação
09/06/2023
País da Publicação
Brasil
Idioma da Publicação
Inglês
Página do Trabalho
https://www.even3.com.br/anais/v-gbmeeting/609499-study-of-regulatory-proteins-in-salmonella-enterica-and-shigella-flexneri
ISBN
978-85-5722-785-9
Palavras-Chave
Salmonella enterica, Shigella flexneri, regulatory proteins, animal models, HU, ProQ
Resumo
Salmonella enterica and Shigella flexneri are part of the major foodborne pathogens associated to diarrheal diseases and systemic infections. The treatment of these infections is usually based in antibiotics that together with its misuse has led to the rise of antibiotic resistant and multi-resistant bacterial strains. That’s the reason why there is an increasing need to finding novel drug therapies and a better understanding of pathogenesis mechanisms and regulatory proteins can be a helpful tool in the comprehension of antibiotic resistance mechanisms as well as the discovery of new therapies targets. That’s why the aim of this project is to study the function of regulatory proteins in Salmonella and Shigella trough the genic deletion and molecular and phenotypic analysis. The attenuation of mutant strains will be assessed using the C. elegans and G. mellonella alternative animal models. Furthermore, we will try to clarify the role of HU protein in the physiology of Shigella flexneri as well as proposed it as a potential target for the development of new therapies. Finally, will be made complementary studies of ProQ protein in Salmonella enterica. Preliminary results shown that ?proQ mutants are attenuated in the C. elegans and G. mellonella models.
Título do Evento
V GBMeeting
Cidade do Evento
Campinas
Título dos Anais do Evento
Anais do GBMeeting: Encontro Anual da Pós Graduação em Genética e Biologia Molecular da UNICAMP
Nome da Editora
Even3
Meio de Divulgação
Meio Digital
DOI
LinkObter o DOI

Como citar

FLOREZ, Yessica Paola Jaimes et al.. STUDY OF REGULATORY PROTEINS IN SALMONELLA ENTERICA AND SHIGELLA FLEXNERI.. In: Anais do GBMeeting: Encontro Anual da Pós Graduação em Genética e Biologia Molecular da UNICAMP. Anais...Campinas(SP) Unicamp, 2023. Disponível em: https//www.even3.com.br/anais/v-gbmeeting/609499-STUDY-OF-REGULATORY-PROTEINS-IN-SALMONELLA-ENTERICA-AND-SHIGELLA-FLEXNERI. Acesso em: 20/06/2024

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