COMPARATIVE EFFECT OF TRANSCRANIAL AND LOCAL PHOTOBIOMODULATION ON PERIPHERAL INFLAMMATION CONTROL IN A COLLAGENASE-INDUCED TENDINITIS EXPERIMENTAL MODEL

Marcia Aparecida Makabe; Caroline Chaves Bittencourt; Rodrigo Labat Marcos

Título del Trabajo

Autores

Marcia Aparecida Makabe
Caroline Chaves Bittencourt
Rodrigo Labat Marcos

Modalidad

Protocolos de investigación

Área temática

Medicina

Fecha de publicación

14/08/2026

País de publicación

Argentina | Argentina

Idioma de la Publicación

es-419

Página del Trabajo

https://www.even3.com.br/anais/ii-encuentro-biofotonica-597461/1258716-comparative-effect-of-transcranial-and-local-photobiomodulation-on-peripheral-inflammation-control-in-a-collagen

ISBN

978-65-272-2678-9

Palabras Clave

Tendinitis, Transcranial photobiomodulation, Inflammatory mediators, Neurokinin-1, Interleukin.

Resumen

Introdution: Transcranial photobiomodulation (TcPBM) is a relatively recent therapeutic approach used in the treatment of various central and peripheral disorders; however, the mechanisms underlying its effects on peripheral inflammatory processes remain poorly understood. The experimental model of collagenase-induced tendinitis in the calcaneal tendon is widely used and considered an excellent model for studying acute inflammatory responses. Objetive: This study aims to evaluate the effects of TcPBM on the inflammatory process in a collagenase-induced calcaneal tendinitis model in mice. Methods: Twenty-one female C57BL/6 mice will be randomly assigned into three experimental groups (n = 7): Group 1 – tendinitis without treatment (NT); Group 2 – tendinitis treated with transcranial photobiomodulation (TcPBM); and Group 3 – tendinitis treated with local photobiomodulation (LPBM) applied directly to the calcaneal tendon. Tendinitis will be induced by transcutaneous injection of type I collagenase into the calcaneal tendon. Transcranial or local irradiation will be performed 30 minutes after tendinitis induction, using the following parameters: (Laser; 808 nm; 3J; 100mW; 60s). Twelve hours after induction, the animals will be euthanized, and the tendons collected for histological analysis (inflammatory cell infiltration and tissue organization) and evaluation of inflammatory markers (gene expression of COX-2, IL-1β, IL-6, IL-10, and neurokinin-1). Expected results: TcPBM is expected to modulate the inflammatory process, promoting resolution of tendinitis.

Título del Evento: II Encuentro Latinoamericano de Investigación y Práctica en Biofotónica y I Seminario de Investigación de Posgrado en Salud
Ciudad del Evento: Buenos Aires
Título de las Actas del Evento: Actas II Encuentro Latinoamericano de Investigación y Práctica en Biofotónica y I Seminario de Investigación de Posgrado en Salud
Nombre de la Editora: Even3
Medio de Divulgación: Meio Digital

Como citar

MAKABE, Marcia Aparecida; BITTENCOURT, Caroline Chaves; MARCOS, Rodrigo Labat. COMPARATIVE EFFECT OF TRANSCRANIAL AND LOCAL PHOTOBIOMODULATION ON PERIPHERAL INFLAMMATION CONTROL IN A COLLAGENASE-INDUCED TENDINITIS EXPERIMENTAL MODEL.. In: Actas II Encuentro Latinoamericano de Investigación y Práctica en Biofotónica y I Seminario de Investigación de Posgrado en Salud. Anais...Sao Paulo(SP) UNIMAIMONIDES, 2026. Disponible en: https//www.even3.com.br/anais/II-Encuentro-Biofotonica-597461/1258716-COMPARATIVE-EFFECT-OF-TRANSCRANIAL-AND-LOCAL-PHOTOBIOMODULATION-ON-PERIPHERAL-INFLAMMATION-CONTROL-IN-A-COLLAGEN. Acceso en: 21/08/2026