EFFECTS OF TRANSCUTANEOUS VASCULAR LASER IRRADIATION ON VENOUS ULCERS: A RANDOMIZED CONTROLLED TRIAL PROTOCOL

Rosângela A Oliveira; Rebeca Boltes

Todos los trabajos

Trabajo

Título del Trabajo

EFFECTS OF TRANSCUTANEOUS VASCULAR LASER IRRADIATION ON VENOUS ULCERS: A RANDOMIZED CONTROLLED TRIAL PROTOCOL

Autores

Rosângela A Oliveira
Rebeca Boltes

Modalidad

Protocolos de investigación

Área temática

Enfermería

Fecha de publicación

14/08/2026

País de publicación

Argentina | Argentina

Idioma de la Publicación

es-419

Página del Trabajo

https://www.even3.com.br/anais/ii-encuentro-biofotonica-597461/1257528-effects-of-transcutaneous-vascular-laser-irradiation-on-venous-ulcers--a-randomized-controlled-trial-protocol

ISBN

978-65-272-2678-9

Palabras Clave

Intravascular Laser Irradiation of Blood (ILIB), Peripheral blood microscopy, Vascular Photobiomodulation (VPBM), leg venous ulcer.

Resumen

Introduction: Intravascular Laser Irradiation of Blood (ILIB), recently termed Vascular Photobiomodulation (VPBM), is a therapeutic technique that uses low-intensity laser irradiation to modulate oxidative stress, reduce inflammation, and improve microcirculation. VPBM has shown promise in treating diffrent chronic wounds, such as diabetic foot or venous ulcers, which exhibit local and systemic alterations characterized by elevated oxidative stress and persistent inflammation. Peripheral blood microscopy (dark-field and bright-field, DFM) and thermography provide tools to analyze VPBM's effects in these contexts. Objective: to investigate VPBM's effects on systemic and local tissue in patients with venous ulcers by evaluating morphological changes in peripheral blood (DFM) and thermal patterns (thermography) and correlate inflammatory/oxidative markers (IL-6, IL-1β, TNF-α, C-Reactive Protein CRP) with clinical progression and tissue regeneration. Methods: A prospective, randomized, controlled trial (SPIRIT-compliant) will be conducted after ethics committee approval. Twenty participants with unilateral right leg venous ulcers will be enrolled according to the following criteria: patients with chronic venous ulcers lasting more than six months, with unilateral right leg venous ulcers and aged between 18 and 70 years. Patients with hematological diseases and severe systemic infections will be excluded. All participants will be randomized into: Intervention group (standard care + trasncutaneous VPBM application over the radial artery, 660 nm, 100 mW, 60 minutes/session, 360 J/session, twice weekly for 4 weeks) and control group (standard care alone). Peripheral blood markers (IL-6, IL-1β, TNF-α, CRP), DFM, and thermographic imaging will be performed at baseline (Day 1) and Days 7, 14, and 21. Epidemiological data will be collected from medical records. Adverse effects will be monitored. Data normality will be assessed using the Kolmogorov-Smirnov test. Parametric or non-parametric tests will compare pre- and post-intervention outcomes within and between groups (SPSS IBM; *p* < 0.05). Anonymized data will be analyzed.

Título del Evento: II Encuentro Latinoamericano de Investigación y Práctica en Biofotónica y I Seminario de Investigación de Posgrado en Salud
Ciudad del Evento: Buenos Aires
Título de las Actas del Evento: Actas II Encuentro Latinoamericano de Investigación y Práctica en Biofotónica y I Seminario de Investigación de Posgrado en Salud
Nombre de la Editora: Even3
Medio de Divulgación: Meio Digital

Como citar

OLIVEIRA, Rosângela A; BOLTES, Rebeca. EFFECTS OF TRANSCUTANEOUS VASCULAR LASER IRRADIATION ON VENOUS ULCERS: A RANDOMIZED CONTROLLED TRIAL PROTOCOL.. In: Actas II Encuentro Latinoamericano de Investigación y Práctica en Biofotónica y I Seminario de Investigación de Posgrado en Salud. Anais...Sao Paulo(SP) UNIMAIMONIDES, 2026. Disponible en: https//www.even3.com.br/anais/II-Encuentro-Biofotonica-597461/1257528-EFFECTS-OF-TRANSCUTANEOUS-VASCULAR-LASER-IRRADIATION-ON-VENOUS-ULCERS--A-RANDOMIZED-CONTROLLED-TRIAL-PROTOCOL. Acceso en: 21/08/2026