ANALYSIS OF THE EFFECTS OF PHOTOBIOMODULATION ON COGNITIVE PERFORMANCE IN RATS EXPOSED TO ALCOHOL DURING DEVELOPMENT

GABRIEL ALMEIDA DA SILVA; Gabriel Almeida da Silva

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Trabajo

Título del Trabajo

ANALYSIS OF THE EFFECTS OF PHOTOBIOMODULATION ON COGNITIVE PERFORMANCE IN RATS EXPOSED TO ALCOHOL DURING DEVELOPMENT

Autores

GABRIEL ALMEIDA DA SILVA
Gabriel Almeida da Silva

Modalidad

Protocolos de investigación

Área temática

Medicina

Fecha de publicación

14/08/2026

País de publicación

Argentina | Argentina

Idioma de la Publicación

es-419

Página del Trabajo

https://www.even3.com.br/anais/ii-encuentro-biofotonica-597461/1257500-analysis-of-the-effects-of-photobiomodulation-on-cognitive-performance-in-rats-exposed-to-alcohol-during-develop

ISBN

978-65-272-2678-9

Palabras Clave

Photobiomodulation, cognitive dysfunction, neuroinflammation

Resumen

Alcohol exposure during early development is a significant risk factor for cognitive deficits and neurobehavioral alterations. Animal studies have shown that high doses of ethanol rapidly induce the expression of pro-inflammatory cytokines in the brain, as well as hypolocomotion and loss of postural reflexes—effects that closely mimic binge drinking patterns observed in humans. Despite growing interest in photobiomodulation (PBM) as a therapeutic strategy for neurological disorders such as Alzheimer’s, Parkinson’s disease, and depression, few studies have investigated its potential to reverse cognitive impairments induced by early-life alcohol exposure. In this context, the present study aimed to compare the effects of transcranial PBM on cognitive performance in spontaneously hypertensive rats (SHR) and Wistar rats exposed to alcohol during early development. A total of 30 rats (15 SHR and 15 Wistar) were randomly assigned to four experimental groups per strain: control, alcohol, PBM, and alcohol + PBM (n = 5 per group). Ethanol exposure was performed via intraperitoneal injection (5 g/kg; 25%) on postnatal days (PN) 2, 4, 6, and 8, between 08:00 and 12:00, in accordance with the animals’ circadian rhythm. PBM was applied on PN3, PN5, PN7, PN9, and again on PN100 using an 808 nm laser (100 mW; 4.8 J; 48 s) directed at the frontal region. Cognitive function was assessed during PN45–59 and PN70–83 using the Y-Maze, open field test, and tail suspension test. On PN100, animals were again exposed to acute ethanol (5 g/kg, i.p.), followed by behavioral testing and subsequent euthanasia. Brains were collected, dissected, stored at –80 °C, and analyzed via quantitative PCR and histological examination. Data were processed using GraphPad Prism v8.0.1.

Título del Evento: II Encuentro Latinoamericano de Investigación y Práctica en Biofotónica y I Seminario de Investigación de Posgrado en Salud
Ciudad del Evento: Buenos Aires
Título de las Actas del Evento: Actas II Encuentro Latinoamericano de Investigación y Práctica en Biofotónica y I Seminario de Investigación de Posgrado en Salud
Nombre de la Editora: Even3
Medio de Divulgación: Meio Digital

Como citar

SILVA, GABRIEL ALMEIDA DA; SILVA, Gabriel Almeida da. ANALYSIS OF THE EFFECTS OF PHOTOBIOMODULATION ON COGNITIVE PERFORMANCE IN RATS EXPOSED TO ALCOHOL DURING DEVELOPMENT.. In: Actas II Encuentro Latinoamericano de Investigación y Práctica en Biofotónica y I Seminario de Investigación de Posgrado en Salud. Anais...Sao Paulo(SP) UNIMAIMONIDES, 2026. Disponible en: https//www.even3.com.br/anais/II-Encuentro-Biofotonica-597461/1257500-ANALYSIS-OF-THE-EFFECTS-OF-PHOTOBIOMODULATION-ON-COGNITIVE-PERFORMANCE-IN-RATS-EXPOSED-TO-ALCOHOL-DURING-DEVELOP. Acceso en: 21/08/2026