IMPACT OF AEROBIC TRAINING ON PHYSICAL PERFORMANCE IN AGED MICE SUBMITTED TO PRENATAL ALCOHOL EXPOSURE

Júlio G. C. Batista; Guilherme Rabelo Nasuk; Allan Luís Barboza Atum; Gabriel Almeida da Silva; José Antonio Silva Junior; Bruna Calixto de Jesus.

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Trabajo

Título del Trabajo

IMPACT OF AEROBIC TRAINING ON PHYSICAL PERFORMANCE IN AGED MICE SUBMITTED TO PRENATAL ALCOHOL EXPOSURE

Autores

Júlio G. C. Batista
Guilherme Rabelo Nasuk
Allan Luís Barboza Atum
Gabriel Almeida da Silva
José Antonio Silva Junior
Bruna Calixto de Jesus.

Modalidad

Investigación

Área temática

Educación física

Fecha de publicación

14/08/2026

País de publicación

Argentina | Argentina

Idioma de la Publicación

es-419

Página del Trabajo

https://www.even3.com.br/anais/ii-encuentro-biofotonica-597461/1253654-impact-of-aerobic-training-on-physical-performance-in-aged-mice-submitted-to-prenatal-alcohol-exposure

ISBN

978-65-272-2678-9

Palabras Clave

Prenatal alcohol exposure,Aging,Aerobic exercise, C57BL/6 mice.

Resumen

Prenatal alcohol exposure (PAE) is a major public health issue associated with neurobehavioral and cardiovascular impairments, yet its long-term impact remains less explored. Several authors suggest that exercise can result in improvement of physical performance caused by PAE. However, this evaluation was not performed in middle-aged animals, which simulate the age of increased cardiovascular diseases in humans. OBJECTIVE: This study investigated the effects of PAE on physical performance in aged C57BL/6 mice (18 months old) on physical performance and the potential rehabilitation through exercise. METHODS: Twenty male and twenty female mice were assigned to Control (CT) or PAE groups and further subdivided into Trained (T; 8 weeks of treadmill running, 5 days/week) or Sedentary (S) conditions. Maximal graded treadmill tests were conducted at baseline, and post-intervention (8 weeks). RESULTS: At baseline, PAE mice displayed significantly lower maximal running speeds than CT mice (p<0.0001), with the largest deficits in PAE males. After 8 weeks, aerobic training significantly improved performance in PAE males (p=0.046) and CT females (p=0.018), eliminating the initial gap between PAE and CT males (p=0.667). Trained animals consistently outperformed sedentary counterparts at the end of the intervention (p<0.0001), while sedentary groups maintained or declined in performance, with sedentary PAE males showing the lowest final values. Significant Treatment x Training (p=0.0005) and Sex x Training (p=0.0137) interactions indicated that exercise effects varied by sex and prenatal exposure status. CONCLUSION: These findings demonstrate that aerobic exercise initiated in late adulthood can effectively reverse PAE-induced physical performance deficits in males and protect against age-related functional decline in both sexes. The combination of exercise and photobiomodulation will be applied to test best performances in the experimental groups.

Título del Evento: II Encuentro Latinoamericano de Investigación y Práctica en Biofotónica y I Seminario de Investigación de Posgrado en Salud
Ciudad del Evento: Buenos Aires
Título de las Actas del Evento: Actas II Encuentro Latinoamericano de Investigación y Práctica en Biofotónica y I Seminario de Investigación de Posgrado en Salud
Nombre de la Editora: Even3
Medio de Divulgación: Meio Digital

Como citar

BATISTA, Júlio G. C. et al.. IMPACT OF AEROBIC TRAINING ON PHYSICAL PERFORMANCE IN AGED MICE SUBMITTED TO PRENATAL ALCOHOL EXPOSURE.. In: Actas II Encuentro Latinoamericano de Investigación y Práctica en Biofotónica y I Seminario de Investigación de Posgrado en Salud. Anais...Sao Paulo(SP) UNIMAIMONIDES, 2026. Disponible en: https//www.even3.com.br/anais/II-Encuentro-Biofotonica-597461/1253654-IMPACT-OF-AEROBIC-TRAINING-ON-PHYSICAL-PERFORMANCE-IN-AGED-MICE-SUBMITTED-TO-PRENATAL-ALCOHOL-EXPOSURE. Acceso en: 21/08/2026