EFFECT OF PHOTODYNAMIC THERAPY ON APICAL PERIODONTITIS IN AN EXPERIMENTAL MODEL OF OVALBUMIN (OVA)-INDUCED ASTHMA

Keilla Santos Soares; Karina Brajato; Veridiana Dellê; Tawany Gonçalves Santos; Marcus Vinicius de Moraes; Cintia Estefano Alves; Ana Paula LIgeiro de Oliveira

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Trabajo

Título del Trabajo

EFFECT OF PHOTODYNAMIC THERAPY ON APICAL PERIODONTITIS IN AN EXPERIMENTAL MODEL OF OVALBUMIN (OVA)-INDUCED ASTHMA

Autores

Keilla Santos Soares
Karina Brajato
Veridiana Dellê
Tawany Gonçalves Santos
Marcus Vinicius de Moraes
Cintia Estefano Alves
Ana Paula LIgeiro de Oliveira

Modalidad

Investigación

Área temática

Odontología

Fecha de publicación

14/08/2026

País de publicación

Argentina | Argentina

Idioma de la Publicación

es-419

Página del Trabajo

https://www.even3.com.br/anais/ii-encuentro-biofotonica-597461/1253633-effect-of-photodynamic-therapy-on-apical-periodontitis-in-an-experimental-model-of-ovalbumin-(ova)-induced-asthm

ISBN

978-65-272-2678-9

Palabras Clave

Keywords: asthma, pulmonary inflammation, apical periodontitis, low-level laser therapy, photodynamic therapy.

Resumen

Apical periodontitis (AP) is a chronic infection resulting from pulp necrosis, characterized by destruction of periapical tissues. Asthma is a chronic inflammatory disease of the lower airways, associated with the release of inflammatory mediators. It is known that oral diseases can interfere with pulmonary diseases; therefore, this study evaluated the effects of antimicrobial photodynamic therapy (aPDT) as an adjunct to conventional endodontic treatment in an experimental model of AP associated with asthma. A total of 64 male Balb/C mice were used, divided into 8 groups (n=8): Basal, AP, AP + Endodontic Treatment (ET), AP + ET + aPDT, Asthma + AP, Asthma + AP + ET, Asthma + AP + ET + aPDT, and Asthma + AP + aPDT. AP was induced by coronal access opening for 21 days. Asthma was induced by ovalbumin (OVA – 4 µg) and aluminum hydroxide (days 0 and 14, subcutaneously), followed by orotracheal challenges with OVA (10 g) three times per week for 5–6 weeks. Endodontic treatment included mechanical instrumentation, calcium hydroxide application, and aPDT with methylene blue (0.005%) activated by a diode laser (660 nm, 9 J per point, 90 s). The association between AP and asthma increased (p<0.05) and endodontic treatment reduced (p<0.05) cell migration (macrophages, lymphocytes, neutrophils, and eosinophils) to the lungs compared to the asthma group, as well as IL-1β, IL-4, IL-5, IL-6, IFN-γ, and IL-10 levels, with better results in the groups that received aPDT. Alkaline phosphatase was elevated (p<0.05) in the AP and AP + Asthma groups and reduced (p<0.05) after treatment only in the groups without asthma. It is concluded that AP can worsen pulmonary inflammation in asthmatic individuals, and that aPDT, as an adjuvant, contributes to reducing both local and systemic inflammation.

Título del Evento: II Encuentro Latinoamericano de Investigación y Práctica en Biofotónica y I Seminario de Investigación de Posgrado en Salud
Ciudad del Evento: Buenos Aires
Título de las Actas del Evento: Actas II Encuentro Latinoamericano de Investigación y Práctica en Biofotónica y I Seminario de Investigación de Posgrado en Salud
Nombre de la Editora: Even3
Medio de Divulgación: Meio Digital

Como citar

SOARES, Keilla Santos et al.. EFFECT OF PHOTODYNAMIC THERAPY ON APICAL PERIODONTITIS IN AN EXPERIMENTAL MODEL OF OVALBUMIN (OVA)-INDUCED ASTHMA.. In: Actas II Encuentro Latinoamericano de Investigación y Práctica en Biofotónica y I Seminario de Investigación de Posgrado en Salud. Anais...Sao Paulo(SP) UNIMAIMONIDES, 2026. Disponible en: https//www.even3.com.br/anais/II-Encuentro-Biofotonica-597461/1253633-EFFECT-OF-PHOTODYNAMIC-THERAPY-ON-APICAL-PERIODONTITIS-IN-AN-EXPERIMENTAL-MODEL-OF-OVALBUMIN-(OVA)-INDUCED-ASTHM. Acceso en: 21/08/2026