EFFECT OF PHOTOBIOMODULATION AND/OR CORTICOSTEROID THERAPY ON CHRONIC LUNG INFLAMMATION IN AN EXPERIMENTAL MODEL OF ASTHMA

Marcus Vinicius de Moraes; Cristiano Rodrigo Alvarenga Nascimento; Auriléia Aparecida de Brito; Tawany Gonçalves Santos; Keilla Santos Soares; Cintia Estefano Alves Silva; Ana Paula LIgeiro de Oliveira

Título del Trabajo

Autores

Marcus Vinicius de Moraes
Cristiano Rodrigo Alvarenga Nascimento
Auriléia Aparecida de Brito
Tawany Gonçalves Santos
Keilla Santos Soares
Cintia Estefano Alves Silva
Ana Paula LIgeiro de Oliveira

Modalidad

Investigación

Área temática

Medicina

Fecha de publicación

14/08/2026

País de publicación

Argentina | Argentina

Idioma de la Publicación

es-419

Página del Trabajo

https://www.even3.com.br/anais/ii-encuentro-biofotonica-597461/1253534-effect-of-photobiomodulation-andor-corticosteroid-therapy-on-chronic-lung-inflammation-in-an-experimental-model

ISBN

978-65-272-2678-9

Palabras Clave

asthma, photobiomodulation therapy, pulmonary inflammation, corticorotoids

Resumen

Asthma is characterized by chronic inflammation of the airways. Photobiomodulation therapy (FBM) reduces inflammation, with no side effects. The present study aimed to evaluate the effects of FBM and its combination with corticosteroids (CORT) in an experimental model of ovalbumin-induced chronic pulmonary allergic inflammation (OVA). Balb/C mice were divided into 7 groups: Basal, CORT, FBM, OVA, OVA+CORT, OVA+FBM, OVA+CORT+FBM. Chronic pulmonary allergic inflammation was induced by subcutaneous immunization (SC) with 4 μg of ovalbumin (OVA), mixed with alum (days 0 and 14), and orotracheal challenge with 10 μg of OVA (three days a week for five weeks). The groups treated with FBM were irradiated for 60 seconds with a 660 nm diode laser, 30mW of mean radiant power and 3 J of radiant energy. In the groups treated with CORT, intranasal fluticasone furoate (0.0275 mg/dose) was used. Twenty-four hours after the last treatment, the analysis of cells and mediators of the bronchoalveolar lavage fluid (BAL) was performed. Regarding the OVA group, both treatments reduced (p<0.05) the total number of cells, macrophages, neutrophils, lymphocytes, and eosinophils. With the use of FBM, there was a reduction (p<0.05) in the production of IL-4, IL-5, IL-1 β, TNF-α and IL-13, in addition to an increase (p<0.05) of IL-10 in BAL in all treated groups, when compared to the OV group. In the OVA + CORT, OVA + FBM and OVA + CORT + FBM groups there was a reduction in collagen deposition, mucus production and tracheal hyper-reactivity compared to the OVA group. Also in the groups in which FBM was applied, there was an improvement in pulmonary function in relation to the OVA and OVA + CORT groups. Thus, we demonstrated that both therapies are efficient, although photobiomodulation alone or associated with conventional treatment has a promising role in the treatment of asthma.

Título del Evento: II Encuentro Latinoamericano de Investigación y Práctica en Biofotónica y I Seminario de Investigación de Posgrado en Salud
Ciudad del Evento: Buenos Aires
Título de las Actas del Evento: Actas II Encuentro Latinoamericano de Investigación y Práctica en Biofotónica y I Seminario de Investigación de Posgrado en Salud
Nombre de la Editora: Even3
Medio de Divulgación: Meio Digital

Como citar

MORAES, Marcus Vinicius de et al.. EFFECT OF PHOTOBIOMODULATION AND/OR CORTICOSTEROID THERAPY ON CHRONIC LUNG INFLAMMATION IN AN EXPERIMENTAL MODEL OF ASTHMA.. In: Actas II Encuentro Latinoamericano de Investigación y Práctica en Biofotónica y I Seminario de Investigación de Posgrado en Salud. Anais...Sao Paulo(SP) UNIMAIMONIDES, 2026. Disponible en: https//www.even3.com.br/anais/II-Encuentro-Biofotonica-597461/1253534-EFFECT-OF-PHOTOBIOMODULATION-ANDOR-CORTICOSTEROID-THERAPY-ON-CHRONIC-LUNG-INFLAMMATION-IN-AN-EXPERIMENTAL-MODEL. Acceso en: 21/08/2026