EFFECT OF PHOTOBIOMODULATION ON THE HEALING OF VENOUS ULCERS IN THE LOWER LIMBS: A DOUBLE-BLIND RANDOMIZED CONTROLLED CLINICAL STUDY

Rayana Gonçalves Moreira; Lara Jansiski Motta; Sandra Kalil Bussadori; Kristianne Porta Santos Fernandes; Raquel Agnelli Mesquita-Ferrari; Marcos Antônio Marise; Heitor Vieira Nogueira; Sergio Jordan; MURILO PAVANELLO RODRIGUES MORAES; Anna Carolina Ratto Tempestini Horliana

Título del Trabajo

Autores

Rayana Gonçalves Moreira
Lara Jansiski Motta
Sandra Kalil Bussadori
Kristianne Porta Santos Fernandes
Raquel Agnelli Mesquita-Ferrari
Marcos Antônio Marise
Heitor Vieira Nogueira
Sergio Jordan
MURILO PAVANELLO RODRIGUES MORAES
Anna Carolina Ratto Tempestini Horliana

Modalidad

Protocolos de investigación

Área temática

Medicina

Fecha de publicación

14/08/2026

País de publicación

Argentina | Argentina

Idioma de la Publicación

es-419

Página del Trabajo

https://www.even3.com.br/anais/ii-encuentro-biofotonica-597461/1246112-effect-of-photobiomodulation-on-the-healing-of-venous-ulcers-in-the-lower-limbs--a-double-blind-randomized-contr

ISBN

978-65-272-2678-9

Palabras Clave

photobiomodulation, venous ulcers, varicose ulcers

Resumen

Venous ulcers (VUs) are a major public health issue due to their chronic nature, high recurrence, and significant impact on patients’ quality of life, as well as economic and social burdens. The standard treatment includes topical agents, pharmacotherapy, and compression therapy. Photobiomodulation (PBM) has shown promise in enhancing wound healing and improving patient outcomes. This randomized, controlled, double-blind clinical trial aims to evaluate the efficacy of PBM combined with compression therapy (gold standard) in accelerating the healing of VUs in the lower limbs.A total of 104 participants will be randomly assigned to two groups: the Experimental Group (n=52), receiving PBM (6 J per emitter, 4 red light emitters at 660 nm and 4 infrared emitters at 808 nm, total power 800 mW) combined with compression therapy; and the Control Group (n=52), receiving compression therapy and sham PBM. Treatments will occur twice weekly over 16 weeks (32 sessions total), following routine care at the Lençóis Paulista Health Unit. PBM or sham PBM will be applied by a trained nurse, while outcomes will be assessed weekly by a blinded researcher.The primary outcome of the study will be wound healing, measured by the percentage reduction rate in wound volume over the 16-week treatment period. Secondary outcomes will include changes in wound dimensions, healing rate, adverse effects, wound quality (Bates-Jensen Scale), pain (VAS), quality of life (SF-36), wound temperature (infrared thermography), clinical severity (VCSS), and treatment costs. Wound size will be objectively measured using the Imitowound® app with smartphone images. Data will be analyzed using appropriate statistical tests, including ANOVA or Kruskal-Wallis, chi-square or Fisher’s exact tests, and Kaplan-Meier survival analysis with log-rank testing, considering p < 0.05 as significant. Positive findings may support PBM as a valuable adjunct in VU treatment.

Título del Evento: II Encuentro Latinoamericano de Investigación y Práctica en Biofotónica y I Seminario de Investigación de Posgrado en Salud
Ciudad del Evento: Buenos Aires
Título de las Actas del Evento: Actas II Encuentro Latinoamericano de Investigación y Práctica en Biofotónica y I Seminario de Investigación de Posgrado en Salud
Nombre de la Editora: Even3
Medio de Divulgación: Meio Digital

Como citar

MOREIRA, Rayana Gonçalves et al.. EFFECT OF PHOTOBIOMODULATION ON THE HEALING OF VENOUS ULCERS IN THE LOWER LIMBS: A DOUBLE-BLIND RANDOMIZED CONTROLLED CLINICAL STUDY.. In: Actas II Encuentro Latinoamericano de Investigación y Práctica en Biofotónica y I Seminario de Investigación de Posgrado en Salud. Anais...Sao Paulo(SP) UNIMAIMONIDES, 2026. Disponible en: https//www.even3.com.br/anais/II-Encuentro-Biofotonica-597461/1246112-EFFECT-OF-PHOTOBIOMODULATION-ON-THE-HEALING-OF-VENOUS-ULCERS-IN-THE-LOWER-LIMBS--A-DOUBLE-BLIND-RANDOMIZED-CONTR. Acceso en: 22/08/2026