EFFECT OF PHOTOBIOMODULATION ON THE SALIVARY GLANDS OF PATIENTS WITH HYPOSALIVATION INDUCED BY THE USE OF BENZODIAZEPINES: DOUBLE-BLIND RANDOMIZED PLACEBO-CONTROLLED CLINICAL STUDY

Cicero Dayves da Silva Bezerra; Maria Lucia Zarvos Varellis; Vanessa Cristina Santos Pavesi; Silvia Pachêco; Regiane Silva de Sales; Sandra Kalill Bussadori; Erika da Silva Mello; Vanessa Dalapria; Leticia Cidreira Boaro; Alessandro Melo Deana

Título del Trabajo

Autores

Cicero Dayves da Silva Bezerra
Maria Lucia Zarvos Varellis
Vanessa Cristina Santos Pavesi
Silvia Pachêco
Regiane Silva de Sales
Sandra Kalill Bussadori
Erika da Silva Mello
Vanessa Dalapria
Leticia Cidreira Boaro
Alessandro Melo Deana

Modalidad

Investigación

Área temática

Odontología

Fecha de publicación

14/08/2026

País de publicación

Argentina | Argentina

Idioma de la Publicación

es-419

Página del Trabajo

https://www.even3.com.br/anais/ii-encuentro-biofotonica-597461/1214489-effect-of-photobiomodulation-on-the-salivary-glands-of-patients-with-hyposalivation-induced-by-the-use-of-benzod

ISBN

978-65-272-2678-9

Palabras Clave

photobiomodulation, hyposalivation, depression

Resumen

Introduction: Depression is one of the most common mental illnesses. Benzodiazepines are the mainstay of treatment for those affected by this condition and class of drugs is associated with adverse reactions, one of which is hyposalivation. Saliva performs multiple functions and plays a vital role in protecting oral health. Reduced salivary flow is most often manifested by symptoms of dry mouth, a subjective complaint called hyposalivation. Users of antidepressant medication have a number of important systemic and oral complications, including hyposalivation. The infrared laser has been shown to significantly improve salivary flow in patients with hyposalivation due to diabetes, hypertension and chronic renal failure. Objective: evaluating the volumetric and biochemical parameters of unstimulated and stimulated saliva samples before and after the application of photobiomodulation in patients with depression taking benzodiazepines. Material and Method: Forty-eight participants were included in the protocol, after signing the Informed Consent Form (ICF), they underwent an anamnesis, physical assessment and questionnaires on self-perceived oral health and symptoms related to salivary gland function and were then randomized into two groups: Photobiomodulated (FBM) (n = 24) ; their major salivary glands were irradiated with a diode laser (808nm, 4J per point, 40s) and SHAM (n = 24) , which underwent a simulation. We performed pre- and post-treatment sialometry to compare saliva volume and biochemical analysis, where we measured total proteins and calcium.. Results: 58% of patients believe that hyposalivation related to other oral problems, with hyposalivation being the most prevalent alteration. After the photobiomodulation protocol, the MBF group showed a significant increase in salivary flow, unlike the SHAM group, as well as an increase in biochemical elements. We observed significant differences in both volume and biochemical elements. Conclusion: Photobiomodulation caused a significant improvement in sialometric and biochemical parameters in the samples analyzed from these groups of patients.

Título del Evento: II Encuentro Latinoamericano de Investigación y Práctica en Biofotónica y I Seminario de Investigación de Posgrado en Salud
Ciudad del Evento: Buenos Aires
Título de las Actas del Evento: Actas II Encuentro Latinoamericano de Investigación y Práctica en Biofotónica y I Seminario de Investigación de Posgrado en Salud
Nombre de la Editora: Even3
Medio de Divulgación: Meio Digital

Como citar

BEZERRA, Cicero Dayves da Silva et al.. EFFECT OF PHOTOBIOMODULATION ON THE SALIVARY GLANDS OF PATIENTS WITH HYPOSALIVATION INDUCED BY THE USE OF BENZODIAZEPINES: DOUBLE-BLIND RANDOMIZED PLACEBO-CONTROLLED CLINICAL STUDY.. In: Actas II Encuentro Latinoamericano de Investigación y Práctica en Biofotónica y I Seminario de Investigación de Posgrado en Salud. Anais...Sao Paulo(SP) UNIMAIMONIDES, 2026. Disponible en: https//www.even3.com.br/anais/II-Encuentro-Biofotonica-597461/1214489-EFFECT-OF-PHOTOBIOMODULATION-ON-THE-SALIVARY-GLANDS-OF-PATIENTS-WITH-HYPOSALIVATION-INDUCED-BY-THE-USE-OF-BENZOD. Acceso en: 21/08/2026