BIOACTIVE COMPOUNDS AS MODULATORS OF ADVERSE EFFECTS INDUCED BY BISPHENOL A (BPA) IN MALE AND FEMALE REPRODUCTIVE SYSTEMS IN MOUSE MODELS: A SYSTEMATIC REVIEW

Kewin Henderson Xavier Monteiro; ISABEL CRISTINA QUEIROZ DA COSTA; Ana Beatriz Silva Angelo; Cibele dos Santos Borges

Título do Trabalho

Autores

Kewin Henderson Xavier Monteiro
ISABEL CRISTINA QUEIROZ DA COSTA
Ana Beatriz Silva Angelo
Cibele dos Santos Borges

Modalidade

Resumo simples

Área temática

REVI - Revisão de literatura

Data de Publicação

05/08/2026

País da Publicação

Brasil | Brasil

Idioma da Publicação

pt-BR

Página do Trabalho

https://www.even3.com.br/anais/cobicet2026-628540/1652031-bioactive-compounds-as-modulators-of-adverse-effects-induced-by-bisphenol-a-(bpa)-in-male-and-female-reproductiv

ISSN

2764-0582

Palavras-Chave

Antagonists; Gametogenesis; Infertility; Receptors; Toxicity.

Resumo

Infertility is a global concern that affects approximately 15% of couples; it is a condition that interferes with achieving a natural pregnancy. There are several factors that compromise the male and female reproductive systems in terms of gametogenic parameters. Disruptions to the biological cycle directly and negatively affect reproductive function through endogenous and exogenous factors. Bisphenol A (BPA) acts in the body as a xenoestrogen, which can interact with alpha and beta estrogen receptors (ERa, ERß) and androgen receptors, capable of directly impacting gametogenesis by promoting hormonal dysfunction and morphological changes in the gonads. In the search for alternatives that can mitigate or resolve the problem of induced infertility, natural medicines emerge as viable resources for addressing the current challenge. In this context, there is growing interest in strategies capable of mitigating the adverse effects of environmental contaminants on male and female fertility, thereby protecting the reproductive system. Intervention studies were retrieved from PubMed, Scielo, Scopus, ScienceDirect, and Web of Science using the search terms “(bisphenol A) AND (bioactive compounds) AND (male reproductive system OR female reproductive system) AND (murine models OR rats)” to identify relevant articles. The studies identified were compiled, analyzed, and filtered by two reviewers working independently. The selection process narrowed the initial 1,459 articles down to 10. The data were described, compared, and discussed from the perspective of bioactive compounds as modulators of the adverse effects of BPA in experimental murine models (rats and mice)—adult males and females—on body weight, reproductive organs, sperm performance, estrous cycle, hormonal levels, oxidative markers, and tissue histology. The physiological data demonstrated a reversal of BPA-induced degeneration, stabilization of serum hormone and enzyme levels, and preservation of the cellular structures involved in gametogenesis following treatment with bioactive compounds, regardless of the animal’s sex. Therefore, these bioactive compounds act as estrogen receptor modulators and can be used to counteract the adverse effects of BPA on the male and female reproductive systems.

Título do Evento: VII Congresso Brasileiro Interdisciplinar em Ciência e Tecnologia
Título dos Anais do Evento: Anais do Congresso Brasileiro Interdisciplinar em Ciência e Tecnologia
Nome da Editora: Even3
Meio de Divulgação: Meio Digital

Como citar

MONTEIRO, Kewin Henderson Xavier et al.. BIOACTIVE COMPOUNDS AS MODULATORS OF ADVERSE EFFECTS INDUCED BY BISPHENOL A (BPA) IN MALE AND FEMALE REPRODUCTIVE SYSTEMS IN MOUSE MODELS: A SYSTEMATIC REVIEW.. In: Anais do Congresso Brasileiro Interdisciplinar em Ciência e Tecnologia. Anais...Diamantina(MG) Online, 2026. Disponível em: https//www.even3.com.br/anais/cobicet2026-628540/1652031-BIOACTIVE-COMPOUNDS-AS-MODULATORS-OF-ADVERSE-EFFECTS-INDUCED-BY-BISPHENOL-A-(BPA)-IN-MALE-AND-FEMALE-REPRODUCTIV. Acesso em: 29/08/2026