Anais do XXIII Congresso Brasileiro de Parasitologia Veterinária

EVALUATION OF THE THERAPEUTIC EFFICACY OF FLURALANER CHEWABLE TABLETS (BRAVECTO®) AGAINST NEW WORLD SCREWWORM (COCHLIOMYIA HOMINIVORAX) INFESTATION IN DOGS

Publicado em 24/09/2026 - ISBN: 978-65-272-2733-5

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Título do Trabalho
EVALUATION OF THE THERAPEUTIC EFFICACY OF FLURALANER CHEWABLE TABLETS (BRAVECTO®) AGAINST NEW WORLD SCREWWORM (COCHLIOMYIA HOMINIVORAX) INFESTATION IN DOGS
Autores
  • Ana Clara Moreira Pessôa Monteiro
  • Jamille Bispo de Carvalho Teixeira
  • Thammy Vieira Bitar
  • Isaac Leão Queiroz Neto
  • Renata joana Costa cruz
  • George Rego Albuquerque
  • Jéssica Fontes Veloso
  • Fernando de Almeida Borges
  • Maykko Antônyo Bravo de Paula
  • Caroline Kaori Arakaki
  • Maria Eduarda Costa Sales
  • Giovanna Espindola
  • Andressa Martins da Nobrega
  • Camila de Carvalho Mariano
  • Rafael Chiummo
  • Luis Vettorato
  • Fabiano Orsi da Silva
  • Frank Guerino
  • Renata Santiago Alberto Carlos
Modalidade
Resumo
Área temática
Entomologia e acarologia
Data de Publicação
24/09/2026
País da Publicação
Brasil
Idioma da Publicação
pt-BR
Página do Trabalho
https://www.even3.com.br/anais/23-congresso-brasileiro-de-parasitologia-veterinaria-673729/1558215-evaluation-of-the-therapeutic-efficacy-of-fluralaner-chewable-tablets-(bravecto%ae)-against-new-world-screwworm-(c
ISBN
978-65-272-2733-5
Palavras-Chave
Bicheira, Myiasis, Isoxazoline, Bravecto, Public Health
Resumo
New World screwworm (NWS), caused by the dipteran Cochliomyia hominivorax, remains a significant challenge in Neotropical regions, causing extensive tissue damage, severe pain, and potential secondary infections in domestic animals and humans. While traditional management has historically relied on labor-intensive topical applications, systemic treatments with isoxazolines offer a more practical and reliable approach for clinical control. This multicenter clinical study evaluated the larvicidal efficacy of a single oral administration of fluralaner (Bravecto®) in dogs naturally infested with C. hominivorax in endemic regions of Brazil. Fifteen privately owned dogs of various breeds and ages, presenting natural infestations of differing severities, were treated with chewable tablets at the approved dose ranging from 25 to 56 mg/kg. Detailed clinical evaluations were performed 24 hours post-administration (day 1). At this time point, wounds were inspected, and all larvae expelled or remaining within the lesion were collected, counted, and classified as live or dead based on motility. Furthermore, live-expelled third-instar (L3) larvae were transferred to 500 mL containers with a pupation substrate and maintained under controlled laboratory conditions to monitor pupation and adult emergence. The treatment achieved a 100% wound clearance, with no living parasites remaining within the lesions of any animal at 24 hours post-treatment. The total larvicidal efficacy was 94.36%, reflecting the combined mortality of intralesional and expelled parasites. A larval expulsion rate of 13.99% (206/1,472) was observed, with 83 specimens (5.63%) being expelled alive. Notably, none of these live-expelled larvae successfully developed into adult flies (0% emergence rate). This indicates that fluralaner exposure, even if not immediately lethal, induces irreversible physiological damage that successfully prevents the completion of the parasite’s life cycle. No adverse events were reported, confirming the product’s high safety standards. These results demonstrate that fluralaner provides a rapid larvicidal effect and offers a practical, systemic alternative to traditional larvicidal treatments, significantly improving the clinical management of canine myiasis and contributing to the control of this important zoonotic parasite. Beyond individual clinical recovery, the interruption of the parasite's life cycle provides a crucial epidemiological benefit by reducing environmental contamination and fly population density. Such findings open new perspectives for integrating isoxazolines into broader public health and One Health strategies aimed at controlling and mitigating the geographic expansion of NWS outbreaks in endemic regions.
Título do Evento
23º Congresso Brasileiro de Parasitologia Veterinária
Cidade do Evento
Belo Horizonte
Título dos Anais do Evento
Anais do XXIII Congresso Brasileiro de Parasitologia Veterinária
Nome da Editora
Even3
Meio de Divulgação
Meio Digital

Como citar

MONTEIRO, Ana Clara Moreira Pessôa et al.. EVALUATION OF THE THERAPEUTIC EFFICACY OF FLURALANER CHEWABLE TABLETS (BRAVECTO®) AGAINST NEW WORLD SCREWWORM (COCHLIOMYIA HOMINIVORAX) INFESTATION IN DOGS.. In: Anais do XXIII Congresso Brasileiro de Parasitologia Veterinária. Anais...Belo Horizonte(MG) Centro de Atividades Didáticas I (CAD 1) da Universidade Federal de Minas Gerais (UFMG), 2026. Disponível em: https//www.even3.com.br/anais/23-congresso-brasileiro-de-parasitologia-veterinaria-673729/1558215-EVALUATION-OF-THE-THERAPEUTIC-EFFICACY-OF-FLURALANER-CHEWABLE-TABLETS-(BRAVECTO%ae)-AGAINST-NEW-WORLD-SCREWWORM-(C. Acesso em: 24/10/2026

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