Annals of the XIII International Fungal Biology Conference (IFBC) & IV International Symposium on Fungal Stress (ISFUS)

BUILDING-UP TISSUE INVASIVE FILAMENTOUS CELLS – CANDIDA ALBICANS’S APPROACH TO STAYING POLARIZED

Published in 13/12/2022 - ISBN: 978-85-5722-449-0

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Paper Title
BUILDING-UP TISSUE INVASIVE FILAMENTOUS CELLS – CANDIDA ALBICANS’S APPROACH TO STAYING POLARIZED
Authors
  • Miguel A. Basante-Bedoya, Rocio Garcia-Rodas
  • Hayet Labbaoui, Stephanie Bogliolo
  • Robert Arkowitz
  • BASSILANA Martine
Modality
Resumo
Subject area
IFBC - Morphogenes
Publishing Date
13/12/2022
Country of Publishing
Brasil
Language of Publishing
Inglês
Paper Page
https://www.even3.com.br/anais/isfus2021/520964-building-up-tissue-invasive-filamentous-cells--candida-albicanss-approach-to-staying-polarized
ISBN
978-85-5722-449-0
Keywords
morphogenesis, polarized filamentous growth, lipids, membrane traffic.
Summary
Our group has been studying the roles of small GTPases and lipids during hyphal morphogenesis in the human fungal pathogen Candida albicans (Bassilana et al. 2020). Using different approaches, such as optogenetics and synthetic physical interactions, together with live-cell microscopy and three-dimensional electron microscopy, we determined the importance and dynamics of membrane traffic components during this process, as well as the organization of the C. albicans secretory pathway. Furthermore, using PDMS micro-fabrication approaches, we probed the ability of filamentous C. albicans cells to penetrate into and grow in substrates of different stiffness (Puerner et al. 2020), and determined how cell growth and morphology are altered during this invasive process. I will discuss how C. albicans responds to external signal to generate invasive filamentous cells, with particular focus on lipids. More specifically the role of phospholipids, including phosphatidylinositol-4-phosphate [PI(4)P] (Garcia-Rodas et al. 2022), and lipid transporters, such as lipid flippases, will be discussed. References: Bassilana M., Puerner C., Arkowitz R.A. External signal-mediated polarized growth in fungi. Curr Opin Cell Bio . 2020;62:150-158. Puerner C., Kukhaleishvili N., Thomson D., Schaub S., Noblin X., Seminara A., Bassilana M., Arkowitz R.A.. Mechanical force-induced morphology changes in a human fungal pathogen. BMC Biol. 2020;18(1):122. Garcia-Rodas R., Labbaoui H., Orange F., Solis N., Zaragoza O., Filler S.G., Bassilana M., Arkowitz R.A. Plasma Membrane Phosphatidylinositol-4-Phosphate Is Not Necessary for Candida albicans Viability yet Is Key for Cell Wall Integrity and Systemic Infection. mBio. 2022;13(1):e0387321. Acknowledments: Our work is supported by the CNRS, ANR (ANR-11-LABX-0028-01, ANR-16-CE13-0010-01, and ANR-19-CE13-0004-01), and EU H2020 (MSCA-ITN-2015-675407) grants. POSTER PRESENTATION
Title of the Event
IV International Symposium on Fungal Stress - ISFUS & International Fungal Biology Conference - IFBC
City of the Event
São José dos Campos
Title of the Proceedings of the event
Annals of the XIII International Fungal Biology Conference (IFBC) & IV International Symposium on Fungal Stress (ISFUS)
Name of the Publisher
Even3
Means of Dissemination
Meio Digital

How to cite

GARCIA-RODAS, Miguel A. Basante-Bedoya, Rocio et al.. BUILDING-UP TISSUE INVASIVE FILAMENTOUS CELLS – CANDIDA ALBICANS’S APPROACH TO STAYING POLARIZED.. In: Annals of the XIII International Fungal Biology Conference (IFBC) & IV International Symposium on Fungal Stress (ISFUS). Anais...São José dos Campos(SP) Hotel Nacional Inn, 2022. Available in: https//www.even3.com.br/anais/ISFUS2021/520964-BUILDING-UP-TISSUE-INVASIVE-FILAMENTOUS-CELLS--CANDIDA-ALBICANSS-APPROACH-TO-STAYING-POLARIZED. Access in: 07/08/2025

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